Using new gene-editing CRISPR technology, a team of researcher at Washington University School of Medicine rewired stem cells’ genetic circuits to autonomously produce a biologic anti-inflammatory arthritis drug when the cells encounter inflammation. The technique eventually could act as a vaccine for arthritis and other chronic conditions. Researchers successfully rewired mouse stem cells to fight inflammation. Such stem cells, known as SMART cells (Stem cells Modified for Autonomous Regenerative Therapy), could one day replace arthritic cartilage and simultaneously protect joints and other tissues from damage that occurs with chronic inflammation.